Resistance in Gram-Negative Organisms: Studying Intervention Strategies

R-GNOSIS “Resistance in Gram-Negative Organisms: Studying Intervention Strategies" is a European collaborative research project awarded 11.9 Million Euro funding from the European Commission under the Seventh Framework Programme (FP7) for Research and technology.

Lasting 5 years, R-GNOSIS aims at determining the efficacy and effectiveness of cutting-edge interventions to reduce carriage, infection and spread of Multi-Drug resistant Gram-negative Bacteria (MDR-GNB).

The project combines five international clinical studies, all supported by highly innovative microbiology, mathematical modelling and data management.

The five clinical studies will investigate the following interventions:

  • A Point-Of-Care-Testing guided management strategy to improve appropriate antibiotic prescription for uncomplicated UTI in primary care
  • Gut decolonization followed by fecal microbiota transplantation in outpatients with intestinal carriage of MDR-GNB
  • A “test and prescribe” strategy, based on rapid diagnostic testing of faeces for MDR-GNB to optimize antibiotic prophylaxis in colo-rectal surgery
  • Contact Isolation of patients with ESBL-producing Enterobacteriaceae in general hospital wards
  • Three Decolonization strategies in ICUs

Seven laboratories across Europe will perform microbiological analyses, as well as unique quantitative experiments. All information will be integrated by three groups of mathematical modellers into highly innovative models to better understand and predict future trends and effects of interventions.

The studies and analyses proposed in R-GNOSIS will generate a step-change in identifying evidence-based preventive measures and clinical guidance for primary care and hospital-based physicians and health-care authorities, to combat the spread and impact of infections caused by MDR-GNB in Europe.

R-GNOSIS is coordinated by Marc Bonten (UMC Utrecht) and brings together a multidisciplinary team with complementary expertise of clinicians, microbiologists and epidemiologists, infectious disease specialists, caregivers in inpatient care and mathematical modellers. The R-GNOSIS consortium is made of 19 partners from 9 countries which include United Kingdom, Denmark, Germany, Netherlands, Belgium, France, Spain, Switzerland and Israel.

More about R-GNOSIS

Primary Objective

To develop and evaluate cutting-edge interventions to reduce carriage, infection and spread of Multi-Drug resistant Gram-negative Bacteria (MDR-GNB)

General Practice Research on Infections Network Meeting 2015 - 2-3 October 2015 - Galway, Ireland
General Practice Research on Infections Network Meeting 2015 - 2-3 October 2015 - Galway, Ireland
Location: http://www.conference.ie/Conferences/index.asp?Conference=436

The General Practice Research on Infections Network Meeting took place on 2-3 October 2015 in Galway, Ireland.

19th Nordic Congress of General Practice - 16-18 June 2015 - Gothenburg, Sweden
19th Nordic Congress of General Practice - 16-18 June 2015 - Gothenburg, Sweden
Location: http://www.nordicgp2015.se/programme

The 19th Nordic Congress of General Practice took place on 16-18 June 2015 in Gothenburg, Sweden.

3rd ICPIC - 16-19 June 2015 - Geneva, Switzerland
3rd ICPIC - 16-19 June 2015 - Geneva, Switzerland
Location: http://www.icpic.com/index.php/conferences/icpic-2015

The 3rd International Conference on Prevention & Infection Control (ICPIC) took place from 16 to 19 June 2015 in Geneva, Switzerland. Chaired by Prof Didier Pittet and co-chaired by Prof Stephan Harbarth.