The R-GNOSIS (Resistance in Gram-Negative Organisms: Studying Intervention Strategies) project combines five international clinical intervention studies, all supported by highly innovative microbiology and mathematical modelling, to determine – in the most relevant patient populations – the efficacy and effectiveness of cutting-edge interventions to reduce acquisition, carriage, infection and spread of Multi-Drug Resistant Gram-negative Bacteria (MDR-GNB).

All clinical work packages (WPs) will progress science beyond the state-of-the-art in generating new and translational clinically relevant knowledge, through hypothesis-driven studies with a focus on patient-centred outcomes that matter to the people of Europe and beyond.

Separate horizontal WPs will deliver transformational project management, data management and dissemination.

The studies and analyses proposed in R-GNOSIS will generate a step-change in identifying evidence-based preventive measures and clinical guidance for primary care and hospital-based physicians, as well as health-care authorities, to combat the spread and impact of the unprecedented rise of infections caused by MDR-GNB in Europe.

Starting date: 1 October 2011

Term: 5 years

Coordinator: University Medical Center Utrecht (Prof Marc Bonten)

Partners: Clinicians, microbiologists and epidemiologists, infectious disease specialists, caregivers in inpatient care, mathematical modellers and specialists in data management. The R-GNOSIS consortium is made of 19 partners from 9 countries which include United Kingdom, Denmark, Germany, Netherlands, Belgium, France, Spain, Switzerland and Israel.

Budget: A total budget of 15.6 M€ and a funding support of 11.9 M€ from the European Commission’s 7th Framework Programme.