The primary objective of WP8 is to develop a sound mechanistic and quantitative understanding of the ecological and evolutionary processes determining the within-host dynamics of MDR-GNB and the between-host hospital transmission of these organisms accounting for resistance gene transfer.
The mathematical modelling WP (WP8) will:
- Develop and update multi-compartment models to create applied modelling tools for predicting (long-term) effects of interventions, using data from the clinical trials.
- Quantify the transmissibility of different species and genotypes of MDR-GNB in different hospital settings and the community.
- Build and evaluate within-host models to investigate the dynamics of MDR-GNB using detailed microbiological data of intestinal microbial interaction, derived from the clinical trials.