Journal of Clinical Microbiology, 52(5), 1 May 2014, pp 1741-44, doi: 10.1128/JCM.03614-13
Intensive Care Medicine, 40(4), 1 April 2014, pp 564–571, doi: 10.1007/s00134-014-3225-8
Expert Opinion on Therapeutic Targets, 18(8), 1 August 2014, pp 851-61, doi: 10.1517/14728222.2014.925881

Project Partners

R-GNOSIS is coordinated by Marc Bonten (UMC Utrecht) and brings together a multidisciplinary team with complementary expertise of clinicians, microbiologists and epidemiologists, infectious disease specialists, caregivers in inpatient care and mathematical modellers. The R-GNOSIS consortium is made of 19 partners from 9 countries which include United Kingdom, Denmark, Germany, Netherlands, Belgium, France, Spain, Switzerland and Israel.

Statens Serum Institut, SSI, DK

Statens Serum Institut, SSI, DK

Further Information :

Organizational Activities

Statens Serum Institut is the national reference centre for diagnosis of infectious diseases in Denmark. The Department for Microbiological Surveillance and Research is involved in DANMAP, the Danish monitoring programme for antibiotic resistance and consumption, national surveillance of staphylococci, hospital infection control and antibiotic research in general. Niels Frimodt-Moller (NFM), head of antibiotic research, leads a group including an associate professor in mathematical modelling, 2 post-doctoral researchers, 3 PhDs and several master students. This group, amongst others, is heavily involved in research in urinary tract infections (UTI), ranging from diagnosis of infection, investigation into virulence factors of E. coli, and antibiotic treatment including pk/pd of urinary tract infections. We run several experimental animal models including the ascending urinary tract infection model in mice and have vast experience with the study of antibiotic activity in vitro and in vivo. Within the field of urinary tract infections NFM has supervised 4 published PhDs, and it is the subject of 2 of the present PhDs. NFM holds the patent on the Flexicult-test, which is being further developed for use in general practise.

Role in the Project

Key Personnel

Niels Frimodt-Moller, MD DMSc is the head of Antibiotic Research, and specialist in clinical microbiology since 1986. Has been involved in research in antibiotics since 1977, which includes investigation into diagnosis, virulence, pathogenesis and treatment of UTI. Further, in the latter years been heavily involved in antibiotic resistance including resistance mechanisms, transfer of resistance plasmids in vitro and in vivo, monitoring of resistance and relation to antibiotic use both in humans and in production animals, including transfer of resistance from animals via food to humans. - no image description is available -