Journal of Clinical Microbiology, 52(5), 1 May 2014, pp 1741-44, doi: 10.1128/JCM.03614-13
Intensive Care Medicine, 40(4), 1 April 2014, pp 564–571, doi: 10.1007/s00134-014-3225-8
Expert Opinion on Therapeutic Targets, 18(8), 1 August 2014, pp 851-61, doi: 10.1517/14728222.2014.925881

Project Partners

R-GNOSIS is coordinated by Marc Bonten (UMC Utrecht) and brings together a multidisciplinary team with complementary expertise of clinicians, microbiologists and epidemiologists, infectious disease specialists, caregivers in inpatient care and mathematical modellers. The R-GNOSIS consortium is made of 19 partners from 9 countries which include United Kingdom, Denmark, Germany, Netherlands, Belgium, France, Spain, Switzerland and Israel.

University of Southampton, SU, UK

University of Southampton, SU, UK

Organizational Activities

The University of Southampton is among the leading European Universities for randomised controlled trials for acute infections in primary care. In the last 5 years the department has lead more than 15 trials, the most important of which are several trials in Respiratory Tract Infections (RTIs: sore throat, otitis media, chest infections, sinusitis). The primary care group is the lead institution for two of the largest randomised trials for acute LRTI to date, conducted as part of the GRACE NOE consortium (the first placebo controlled trial in over 2000 patients is completed and the second trial to modify antibiotic use among more than 4000 patients has also completed). The group has lead as series of recent high profile studies in urinary tract infection – including validation studies, observational studies and a randomised controlled trial of management strategies. The University of Southampton will lead one of the centres in the primary care workpackage.

Role in the Project

Key Personnel

Paul Little, Professor Little trained in health services research and epidemiology statistics at the London School of Hygiene and Tropical Medicine, and has considerable expertise in a variety of methodologies, but particularly pragmatic trials. He was past chairman of GRIN (the General Practice Respiratory Infections Network), has advised both the US (AHCPR) and several UK government bodies (NICE; MeReC; the House of Lords) on the management of infections, and was part of the working group advising the MRC about the future of clinical trials in the MRC. He was a member of the primary care panel for the UK 2008 Research Assessment Exercise, a member of the Research Excellence Framework  panel and on the UK NIHR Programme Funding Board. - no image description is available -
Michael Moore, Dr Moore is GP in Salisbury and Reader in the Southampton group. He has been a key member of the group in developing the trial protocols and trial management for most of the successful primary care trials lead by Southampton. He is leading a NSPCR grant looking at non antibiotic treatments for adult female UTI and is the RCGP National Clinical Champion for antimicrobial stewardship.  He has excellent links with local research practices through the South West Primary Care Research Network. - no image description is available -