Journal of Clinical Microbiology, 52(5), 1 May 2014, pp 1741-44, doi: 10.1128/JCM.03614-13
Intensive Care Medicine, 40(4), 1 April 2014, pp 564–571, doi: 10.1007/s00134-014-3225-8
Expert Opinion on Therapeutic Targets, 18(8), 1 August 2014, pp 851-61, doi: 10.1517/14728222.2014.925881

Project Partners

R-GNOSIS is coordinated by Marc Bonten (UMC Utrecht) and brings together a multidisciplinary team with complementary expertise of clinicians, microbiologists and epidemiologists, infectious disease specialists, caregivers in inpatient care and mathematical modellers. The R-GNOSIS consortium is made of 19 partners from 9 countries which include United Kingdom, Denmark, Germany, Netherlands, Belgium, France, Spain, Switzerland and Israel.

Université de Fribourg, UNIFR, CH

Université de Fribourg, UNIFR, CH

Organizational Activities

The University of Fribourg (UNIFR) is Switzerland’s only bilingual university, offering a full academic curriculum both in French and German. A number of Master programmes are taught in English as well and the University offers a wide range of opportunities for PhD and postdoctoral studies in all the five faculties.

The Department of Medicine is part of the Faculty of Sciences and has as a strong tradition of excellence in teaching and in research in preclinical disciplines. With the expansion of the medical training, the clinical medicine was reinforced and new research topics were initiated. It includes specialties such as cardiology, endocrinology, microbiology, neurology, pathology, pharmacology and psychiatry. Prof Patrice Nordmann heads the Chair of Microbiology.

The group of Prof Nordmann is working on genetics, biochemistry and molecular epidemiology of the emerging resistance determinants (mostly in Gram negative rods, i.e Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter baumannii) including evaluation of novel antibiotic molecules. Prof Nordmann is particularly interested in emerging antibiotic resistance traits that are spreading, mostly currently, carbapenemases. His group has identified several natural reservoirs of antibiotic ressistance genes and was the first reproducing gene mobility to human pathogens (CTX-M, Enterobacteriacae). Identification of totally novel genetic elements as vector of antibiotic resistance genes and antibiotic resistance traits has been extensively performed. Prof Nordmann has developed recently novel rapid diagnosis techniques for detection of broad-spectrum resistance traits (ESBLs, carbapenemases) emerging in Gram negatives that shall contribute to the control of their spread worldwide.

Role in the Project

Key Personnel

Patrice Nordmann (MD, PhD) is head the Medical and Molecular Microbiology Unit of the Department of Medicine of University of Fribourg. He has gained extensive knowledge in genetics and biochemistry of antibiotic resistance. He has been principal and co -investigator of projects funded either by national or international, private or public grant agencies (COBRA and DRESP2 in the FP6,). He is the member of editorial board of several journals including Antimicrobial Agents and Chemotherapy and Emerging Infectious Diseases. He has co-authored more than 380 articles published in peer-reviewed and English-written journals. - no image description is available -
Laurent Poirel (PhD) is an internationally recognized expert in the field of molecular biology and antibiotic resistance. He has developed recently research projects aimed to analyze spread of antibiotic resistance genes in the environment and their reservoir at the species level. He has co-authored more than 230 original articles in peer-reviewed journals. - no image description is available -